B4GALT6 - Beta-1,4-galactosyltransferase 6 - human protein (Function)
 
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Protein
Gene
References

 
B4GALT6 »  Beta-1,4-galactosyltransferase 6
 
Gene name:  B4GALT6
Family name: Glycosyltransferase 7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for the biosynthesis of glycosphingolipids.  
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  • CuratedUniProtKB
GO molecular function 
Galactosyltransferase activitydefinition[GO:0008378]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.-: UDP-galactose + glucosylceramide UDP + lactosylceramide.  
3
  • CuratedUniProtKB
EC 2.4.1.274: UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.  
3
  • CuratedUniProtKB
It requires the following cofactor
Manganese or magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by EDTA (By similarity).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 7  GT7  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+9331  
Sphingolipid metabolism  hsa00600+9331  
According to Reactome, this protein belongs to the following pathways:
Keratan sulfate biosynthesis  REACT_121120  
N-Glycan antennae elongation  REACT_25085  
O-linked glycosylation of mucins  REACT_115606  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 3 uM for glucosylceramide
KM 0.5 uM for UDP-galactose
Vmax 0.06 nmol/h/mg enzyme toward glucosylceramide
Vmax 86 nmol/h/mg enzyme toward UDP-galactose

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9331
PRO: PR:Q9UBX8