LPAR3 - Lysophosphatidic acid receptor 3 - human protein (Function)
 
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LPAR3 »  Lysophosphatidic acid receptor 3  (LPA-3)
 
Protein also known as:  Lysophosphatidic acid receptor Edg-7.
Gene name:  LPAR3
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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Overview 
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.  
  • CuratedUniProtKB
GO molecular function 
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
  • IEAOrtholog Compara
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Lipid bindingdefinition[GO:0008289]  
1
  • TASPINC
Lysophosphatidic acid receptor activitydefinition[GO:0070915] silver  
  • IEAInterPro 2 GO
Phospholipid bindingdefinition[GO:0005543] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Bleb assemblydefinition[GO:0032060] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Positive regulation of calcium ion transportdefinition[GO:0051928] silver  
  • IEAOrtholog Compara
Positive regulation of collateral sproutingdefinition[GO:0048672] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+23566  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
Lysosphingolipid and LPA receptors  REACT_18365  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LPAR3
GenomeRNAi: 23566
PRO: PR:Q9UBY5
Chemistry
GuidetoPHARMACOLOGY: 274