MALT1 - Mucosa-associated lymphoid tissue lymphoma translocation protein 1 - human protein (Function)
 
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Protein
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References

 
MALT1 »  Mucosa-associated lymphoid tissue lymphoma translocation protein 1   [ EC 3.4.22.- ]
 
Protein also known as:  MALT lymphoma-associated translocation.
Gene name:  MALT1
Family name: Peptidase C14B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 91 2
GENE REF ISO

Function

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Overview 
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.  
3
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • NASUniProtKB
Contributes to kinase activator activitydefinition[GO:0019209]  
1
  • IMPUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDABHF-UCL
Protease bindingdefinition[GO:0002020] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein self-associationdefinition[GO:0043621]  
1
  • IPIUniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
2
  • IDAUniProtKB
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250]  
1
  • IMPUniProtKB
B-1 B cell differentiationdefinition[GO:0001923] silver  
  • IEAOrtholog Compara
Defense responsedefinition[GO:0006952]  
1
  • NASUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • NASUniProtKB
Nuclear exportdefinition[GO:0051168]  
1
  • IDAUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Positive regulation of interleukin-2 productiondefinition[GO:0032743]  
1
  • IMPUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • NASBHF-UCL
Positive regulation of T cell activationdefinition[GO:0050870]  
1
  • ICUniProtKB
Positive regulation of T cell cytokine productiondefinition[GO:0002726]  
1
  • IMPUniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
2
  • IDAGOC
Proteolysisdefinition[GO:0006508]  
1
  • IDABHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • IDAMGI
Regulation of T cell receptor signaling pathwaydefinition[GO:0050856] silver  
  • IEAOrtholog Compara
Response to fungusdefinition[GO:0009620] silver  
  • IEAOrtholog Compara
Response to molecule of bacterial origindefinition[GO:0002237] silver  
  • IEAOrtholog Compara
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • IDAUniProtKB
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+10892  
T cell receptor signaling pathway  hsa04660+10892  
Tuberculosis  hsa05152+10892  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MALT1
GenomeRNAi: 10892
PRO: PR:Q9UDY8