KL - Klotho - human protein (Function)
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KL »  Klotho   [ EC ]
Cleaved into:  Klotho peptide.
Gene name:  KL
Family name: Glycosyl hydrolase 1 » Klotho
Entry whose protein(s) existence is based on evidence at protein level
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May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).  
  • CuratedUniProtKB
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Beta-glucosidase activitydefinition[GO:0008422]  
Beta-glucuronidase activitydefinition[GO:0004566]  
  • IEAEC 2 GO
Fibroblast growth factor bindingdefinition[GO:0017134]  
  • IPIUniProtKB
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Vitamin D bindingdefinition[GO:0005499]  
  • IEAUniProtKB KW
GO biological process 
Acute inflammatory responsedefinition[GO:0002526] silver  
  • IEAOrtholog Compara
  • IMPUniProtKB
Calcium ion homeostasisdefinition[GO:0055074] silver  
  • IEAOrtholog Compara
Carbohydrate metabolic processdefinition[GO:0005975] silver  
  • IEAInterPro 2 GO
Energy reserve metabolic processdefinition[GO:0006112] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501]  
  • IMPUniProtKB
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwaydefinition[GO:0090080] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC A beta-D-glucuronoside + H(2)O D-glucuronate + an alcohol.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 1  GH1  
According to KEGG, this protein belongs to the following pathways:
Endocrine and other factor-regulated calcium reabsorption  hsa04961+9365  
Metabolic pathways  hsa01100+9365  
Pentose and glucuronate interconversions  hsa00040+9365  
Starch and sucrose metabolism  hsa00500+9365  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1c and Klotho ligand binding and activation  REACT_9484  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Defects in KL may be a cause of chronic renal failure complications.  
  • CuratedUniProtKB


Molecular function 
Glycosidase  definition   [KW-0326]
Hormone  definition   [KW-0372]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Klotho_(biology)
GenomeRNAi: 9365