KL - Klotho - human protein (Sequence)
 
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Protein
Gene
References

 
KL »  Klotho   [ EC 3.2.1.31 ]
 
Cleaved into:  Klotho peptide.
Gene name:  KL
Family name: Glycosyl hydrolase 1 » Klotho
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   1012 aaMass: 116181 Da,  pI: 8.06
MPASAPPRRP RPPPPSLSLL LVLLGLGGRR LRAEPGDGAQ TWARFSRPPA PEAAGLFQGT FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP LGAPSPLQPA TGDVASDSYN NVFRDTEALR ELGVTHYRFS ISWARVLPNG SAGVPNREGL RYYRRLLERL RELGVQPVVT LYHWDLPQRL QDAYGGWANR ALADHFRDYA ELCFRHFGGQ VKYWITIDNP YVVAWHGYAT GRLAPGIRGS PRLGYLVAHN LLLAHAKVWH LYNTSFRPTQ GGQVSIALSS HWINPRRMTD HSIKECQKSL DFVLGWFAKP VFIDGDYPES MKNNLSSILP DFTESEKKFI KGTADFFALC FGPTLSFQLL DPHMKFRQLE SPNLRQLLSW IDLEFNHPQI FIVENGWFVS GTTKRDDAKY MYYLKKFIME TLKAIKLDGV DVIGYTAWSL MDGFEWHRGY SIRRGLFYVD FLSQDKMLLP KSSALFYQKL IEKNGFPPLP ENQPLEGTFP CDFAWGVVDN YIQVDTTLSQ FTDLNVYLWD VHHSKRLIKV DGVVTKKRKS YCVDFAAIQP QIALLQEMHV THFRFSLDWA LILPLGNQSQ VNHTILQYYR CMASELVRVN ITPVVALWQP MAPNQGLPRL LARQGAWENP YTALAFAEYA RLCFQELGHH VKLWITMNEP YTRNMTYSAG HNLLKAHALA WHVYNEKFRH AQNGKISIAL QADWIEPACP FSQKDKEVAE RVLEFDIGWL AEPIFGSGDY PWVMRDWLNQ RNNFLLPYFT EDEKKLIQGT FDFLALSHYT TILVDSEKED PIKYNDYLEV QEMTDITWLN SPSQVAVVPW GLRKVLNWLK FKYGDLPMYI ISNGIDDGLH AEDDQLRVYY MQNYINEALK AHILDGINLC GYFAYSFNDR TAPRFGLYRY AADQFEPKAS MKHYRKIIDS NGFPGPETLE RFCPEEFTVC TECSFFHTRK SLLAFIAFLF FASIISLSLI FYYSKKGRRS YK

Sequence

 show evidences
Domain 
Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 239, and the second one lacks the essential Glu active site residue at position 872.  
  • CuratedUniProtKB
PTM 
N-glycosylated (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.20.20.80
InterPro: IPR013781 [ Glyco hydro catalytic dom ]
InterPro: IPR028546 [ Klotho ]
InterPro: IPR001360 [ Glyco hydro 1 ]
InterPro: IPR018120 [ Glyco hydro 1 AS ]
InterPro: IPR017853 [ Glycoside hydrolase SF ]
PANTHER: PTHR10353:SF10 [ PTHR10353:SF10 ]
PANTHER: PTHR10353 [ PTHR10353 ]
Pfam: PF00232 [ Glyco hydro 1 ]
PRINTS: PR00131 [ GLHYDRLASE1 ]
PROSITE: PS00653 [ GLYCOSYL HYDROL F1 2 ]
SUPFAM: SSF51445 [ SSF51445 ]
Genome annotation databases
Ensembl: Transcript: ENST00000380099;  Protein: ENSP00000369442;  Gene: ENSG00000133116.
Ensembl: Transcript: ENST00000426690;  Protein: ENSP00000399513;  Gene: ENSG00000133116.
KEGG: hsa:9365
UCSC: uc001uus.3
Organism-specific databases
MGI: MGI:1101771 [ Kl ]
Other
PMAP-CutDB: Q9UEF7
PTM databases
PhosphoSite: Q9UEF7
Phylogenomic databases
eggNOG: COG2723
HOGENOM: HOG000060126
HOVERGEN: HBG081856
InParanoid: Q9UEF7
KO: K14756
OMA: ALSSHWI
OrthoDB: EOG7MH0XV
PhylomeDB: Q9UEF7
Sequence databases
CCDS: CCDS9347.1 [ Q9UEF7-1 ]
EMBL: mRNA:  AB005142 . Translation:  BAA23382.1 .
EMBL: Genomic DNA:  AB009667 . Translation:  BAA24940.1 .
EMBL: Genomic DNA:  Z92540 . Translation:  CAC94767.1 .
EMBL: Genomic DNA:  AL161898 . Translation:  CAH71888.1 .
EMBL: Genomic DNA:  AB009667 . Translation:  BAA24941.1 .
EMBL: Genomic DNA:  Z84483 . Translation:  CAC94773.1 .
IPI: IPI00295265
IPI: IPI00170818
PIR: JC5925
PIR: JC5926
RefSeq: Protein:  NP_004786.2. Nucleotide sequence:  NM_004795.3.
UniProtKB: Q9UEF7 [ KL ]