DAXX - Death domain-associated protein 6 - human protein (Function)
 
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DAXX »  Death domain-associated protein 6
 
Protein also known as:  Fas death domain-associated protein.
Gene name:  DAXX
Family name: DAXX
Entry whose protein(s) existence is based on evidence at protein level
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1 166 3
GENE REF ISO

Function

 show evidences
Overview 
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Shows restriction activity towards human cytomegalovirus (HCMV).  
5
  • CuratedUniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • IPIUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Heat shock protein bindingdefinition[GO:0031072]  
1
  • TASUniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • IDAUniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
34
  • IPIIntAct
  • IPIUniProtKB
Isoform  Iso 1   Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
2
  • IPIUniProtKB
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • TASPINC
Isoform  Iso 1   Transcription factor bindingdefinition[GO:0008134]  
1
  • IDAUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • TASPINC
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • IDAUniProtKB
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • TASPINC
Mitotic cytokinesisdefinition[GO:0000281] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IDAUniProtKB
Nucleosome assemblydefinition[GO:0006334]  
1
  • IDAUniProtKB
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of cell deathdefinition[GO:0010942]  
1
  • IGIParkinsonsUK-UCL
Regulation of protein ubiquitinationdefinition[GO:0031396]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAMGI
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+1616  
Herpes simplex infection  hsa05168+1616  
MAPK signaling pathway  hsa04010+1616  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Death-associated_protein_6
GenomeRNAi: 1616
PRO: PR:Q9UER7