EPHA6 - Ephrin type-A receptor 6 - human protein (Function)
 
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Protein
Gene
References

 
EPHA6 »  Ephrin type-A receptor 6   [ EC 2.7.10.1 ]
 
Protein also known as:  EPH homology kinase 2 (EHK-2).
Gene name:  EPHA6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 3
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Ephrin receptor activitydefinition[GO:0005003] silver  
1
  • InterPro 2 GO
GO biological process 
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • InterPro 2 GO
  • UniProtKB KW
  • EC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+285220  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPH-Ephrin signaling  REACT_264068  
EPHA-mediated growth cone collapse  REACT_264548  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHA6
GenomeRNAi: 285220
PRO: PR:Q9UF33
Chemistry
GuidetoPHARMACOLOGY: 1826