EPHA6 - Ephrin type-A receptor 6 - human protein (Function)
 
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Protein
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References

 
EPHA6 »  Ephrin type-A receptor 6   [ EC 2.7.10.1 ]
 
Protein also known as:  EPH homology kinase 2 (EHK-2).
Gene name:  EPHA6
Entry whose protein(s) existence is based on evidence at protein level
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1 29 3
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ephrin receptor activitydefinition[GO:0005003] silver  
  • IEAInterPro 2 GO
GO biological process 
Ephrin receptor signaling pathwaydefinition[GO:0048013] silver  
  • IEAInterPro 2 GO
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+285220  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHA6
GenomeRNAi: 285220
PRO: PR:Q9UF33
Chemistry
GuidetoPHARMACOLOGY: 1826