LRWD1 - Leucine-rich repeat and WD repeat-containing protein 1 - human protein (Function)
 
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Protein
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References

 
LRWD1 »  Leucine-rich repeat and WD repeat-containing protein 1
 
Protein also known as:  Origin recognition complex-associated protein (ORCA).
Gene name:  LRWD1
Family name: LRWD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.  
5
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
2
  • IDAUniProtKB
Methyl-CpG bindingdefinition[GO:0008327]  
1
  • IDAUniProtKB
Methylated histone residue bindingdefinition[GO:0035064]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Chromatin organizationdefinition[GO:0006325]  
1
  • IMPUniProtKB
DNA replication initiationdefinition[GO:0006270]  
1
  • TASUniProtKB
Establishment of protein localization to chromatindefinition[GO:0071169]  
1
  • IDAUniProtKB
 

Keywords

Biological process 
DNA replication  definition   [KW-0235]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 222229
PRO: PR:Q9UFC0