IFT172 - Intraflagellar transport protein 172 homolog - human protein (Function)
 
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Protein
Gene
References

 
IFT172 »  Intraflagellar transport protein 172 homolog
 
Gene name:  IFT172
Family name: IFT172
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity).  
1
  • UniProtKB
GO biological process 
Bone developmentdefinition[GO:0060348] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cilium assemblydefinition[GO:0042384]  
2
  • UniProtKB
  • Ortholog Curator
Cytoplasmic microtubule organizationdefinition[GO:0031122] silver  
1
  • Ortholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
1
  • Ortholog Compara
Epidermis developmentdefinition[GO:0008544] silver  
1
  • Ortholog Compara
Heart loopingdefinition[GO:0001947] silver  
1
  • Ortholog Compara
Hindgut developmentdefinition[GO:0061525] silver  
1
  • Ortholog Compara
Left/right axis specificationdefinition[GO:0070986] silver  
1
  • Ortholog Compara
Limb developmentdefinition[GO:0060173] silver  
1
  • Ortholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Notch signaling pathwaydefinition[GO:0007219] silver  
1
  • Ortholog Compara
Palate developmentdefinition[GO:0060021] silver  
1
  • Ortholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
1
  • Ortholog Compara
Protein processingdefinition[GO:0016485] silver  
1
  • Ortholog Compara
Smoothened signaling pathwaydefinition[GO:0007224] silver  
1
  • Ortholog Compara
Spinal cord motor neuron differentiationdefinition[GO:0021522] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hedgehog 'off' state  REACT_268323  
Intraflagellar transport  REACT_268024  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26160
PRO: PR:Q9UG01