ZRANB1 - Ubiquitin thioesterase ZRANB1 - human protein (Function)
 
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ZRANB1 »  Ubiquitin thioesterase ZRANB1   [ EC 3.4.19.12 ]
 
Protein also known as:  Zinc finger Ran-binding domain-containing protein 1.
Gene name:  ZRANB1
Family name: Peptidase C64
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 1
GENE REF ISO

Function

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Overview 
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.  
4
  • CuratedUniProtKB
GO molecular function 
K63-linked polyubiquitin bindingdefinition[GO:0070530]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
1
  • IMPUniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • IMPUniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IMPUniProtKB
Protein deubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0071947]  
1
  • IMPBHF-UCL
Protein K29-linked deubiquitinationdefinition[GO:0035523]  
1
  • IDAUniProtKB
Protein K33-linked deubiquitinationdefinition[GO:1990168]  
1
  • IDAUniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
2
  • IDAUniProtKB
Regulation of cell morphogenesisdefinition[GO:0022604]  
1
  • IMPUniProtKB
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54764
PRO: PR:Q9UGI0