KCNN3 - Small conductance calcium-activated potassium channel protein 3 - human protein (Function)
 
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Protein
Gene
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KCNN3 »  Small conductance calcium-activated potassium channel protein 3  (SK3)
 
Protein also known as:  KCa2.3.
Gene name:  KCNN3
Entry whose protein(s) existence is based on evidence at protein level
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1 56 3
GENE REF ISO

Function

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Overview 
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.  
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516] silver  
  • IBARefGenome
Small conductance calcium-activated potassium channel activitydefinition[GO:0016286] silver  
  • IBARefGenome
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IBARefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ca2+ activated K+ channels  REACT_75896  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SK3
GenomeRNAi: 3782
PRO: PR:Q9UGI6
Chemistry
GuidetoPHARMACOLOGY: 383