PRKAG2 - 5'-AMP-activated protein kinase subunit gamma-2 - human protein (Function)
 
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PRKAG2 »  5'-AMP-activated protein kinase subunit gamma-2  (AMPK gamma2)
 
Protein also known as:  H91620p.
Gene name:  PRKAG2
Entry whose protein(s) existence is based on evidence at protein level
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1 64 3
GENE REF ISO

Function

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Overview 
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.  
1
  • CuratedUniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531]  
1
  • IDABHF-UCL
AMP bindingdefinition[GO:0016208] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524]  
1
  • IDABHF-UCL
cAMP-dependent protein kinase inhibitor activitydefinition[GO:0004862]  
1
  • IDABHF-UCL
cAMP-dependent protein kinase regulator activitydefinition[GO:0008603]  
1
  • IMPBHF-UCL
Phosphorylase kinase regulator activitydefinition[GO:0008607]  
1
  • IMPBHF-UCL
Protein kinase activator activitydefinition[GO:0030295]  
1
  • IMPBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IDABHF-UCL
GO biological process 
ATP biosynthetic processdefinition[GO:0006754]  
1
  • TASBHF-UCL
Fatty acid biosynthetic processdefinition[GO:0006633]  
  • IEAUniProtKB KW
Glycogen metabolic processdefinition[GO:0005977]  
2
  • IMPBHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IMPBHF-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IDABHF-UCL
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
1
  • IDAGOC
Positive regulation of peptidyl-threonine phosphorylationdefinition[GO:0010800]  
1
  • IMPBHF-UCL
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IMPBHF-UCL
Regulation of fatty acid metabolic processdefinition[GO:0019217]  
1
  • IMPBHF-UCL
Regulation of fatty acid oxidationdefinition[GO:0046320]  
1
  • TASBHF-UCL
Regulation of glucose importdefinition[GO:0046324]  
1
  • TASBHF-UCL
Regulation of glycolytic processdefinition[GO:0006110]  
1
  • IMPBHF-UCL
Sterol biosynthetic processdefinition[GO:0016126]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+51422  
Hypertrophic cardiomyopathy (HCM)  hsa05410+51422  
Insulin signaling pathway  hsa04910+51422  
According to Reactome, this protein belongs to the following pathways:
Activation of PPARGC1A (PGC-1alpha) by phosphorylation  REACT_200686  
AMPK inhibits chREBP transcriptional activation activity  REACT_1988  
Import of palmitoyl-CoA into the mitochondrial matrix  REACT_11082  
Regulation of AMPK activity via LKB1  REACT_21285  
Regulation of Rheb GTPase activity by AMPK  REACT_21393  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PRKAG2
GenomeRNAi: 51422
PRO: PR:Q9UGJ0