CHRNA9 - Neuronal acetylcholine receptor subunit alpha-9 - human protein (Function)
 
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Protein
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References

 
CHRNA9 »  Neuronal acetylcholine receptor subunit alpha-9
 
Protein also known as:  Nicotinic acetylcholine receptor subunit alpha-9 (NACHR alpha-9).
Gene name:  CHRNA9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed11752216, PubMed25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed11752216, PubMed25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed11021840).  
4
  • UniProtKB
GO molecular function 
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889] silver  
1
  • Ortholog Compara
Acetylcholine-gated cation channel activitydefinition[GO:0022848]  
1
  • UniProtKB
Calcium channel activitydefinition[GO:0005262]  
1
  • UniProtKB KW
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • UniProtKB KW
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • MGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+55584  
According to Reactome, this protein belongs to the following pathway:
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA9
GenomeRNAi: 55584
PRO: PR:Q9UGM1
Chemistry
GuidetoPHARMACOLOGY: 469