CHRNA9 - Neuronal acetylcholine receptor subunit alpha-9 - human protein (Function)
 
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CHRNA9 »  Neuronal acetylcholine receptor subunit alpha-9
 
Protein also known as:  Nicotinic acetylcholine receptor subunit alpha-9 (NACHR alpha-9).
Gene name:  CHRNA9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.  
2
  • CuratedUniProtKB
GO molecular function 
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889] silver  
  • IEAOrtholog Compara
Calcium channel activitydefinition[GO:0005262]  
  • IEAUniProtKB KW
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IGIMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+55584  
According to Reactome, this protein belongs to the following pathway:
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA9
GenomeRNAi: 55584
PRO: PR:Q9UGM1
Chemistry
GuidetoPHARMACOLOGY: 469