CD300A - CMRF35-like molecule 8 - human protein (Function)
 
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CD300A »  CMRF35-like molecule 8  (CLM-8)
 
Protein also known as:  Immunoglobulin superfamily member 12 (IgSF12); CD antigen CD300a.
Gene name:  CD300A
Family name: CD300
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 4
GENE REF ISO

Function

 show evidences
Overview 
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.  
3
  • CuratedUniProtKB
GO molecular function 
Phosphatidylethanolamine bindingdefinition[GO:0008429]  
1
  • IDAUniProtKB
Phosphatidylserine bindingdefinition[GO:0001786]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Signaling receptor activitydefinition[GO:0038023]  
2
  • IDAUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Immune system processdefinition[GO:0002376]  
  • IEAUniProtKB KW
Negative regulation of activation of JAK2 kinase activitydefinition[GO:1902569]  
1
  • IDAUniProtKB
Negative regulation of B cell proliferationdefinition[GO:0030889]  
1
  • IMPUniProtKB
Negative regulation of B cell receptor signaling pathwaydefinition[GO:0050859]  
1
  • IDAUniProtKB
Negative regulation of eosinophil activationdefinition[GO:1902567]  
1
  • IDAUniProtKB
Negative regulation of eosinophil migrationdefinition[GO:2000417]  
1
  • IDAUniProtKB
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • IDAUniProtKB
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IDAUniProtKB
Negative regulation of mast cell activation involved in immune responsedefinition[GO:0033007]  
1
  • IDAUniProtKB
Negative regulation of mast cell degranulationdefinition[GO:0043305]  
1
  • IDAUniProtKB
Negative regulation of neutrophil activationdefinition[GO:1902564]  
1
  • IDAUniProtKB
Negative regulation of NK T cell activationdefinition[GO:0051134]  
1
  • IDAUniProtKB
Negative regulation of phagocytosis, engulfmentdefinition[GO:0060101]  
1
  • IMPUniProtKB
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516]  
1
  • IDAUniProtKB
Regulation of T cell receptor signaling pathwaydefinition[GO:0050856]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
2
  • IDAGOC
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Immunity  definition   [KW-0391]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD300A
GenomeRNAi: 11314
PRO: PR:Q9UGN4