AFF4 - AF4/FMR2 family member 4 - human protein (Function)
 
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Protein
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AFF4 »  AF4/FMR2 family member 4
 
Protein also known as:  Major CDK9 elongation factor-associated protein.
Gene name:  AFF4
Family name: AF4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
GO biological process 
Spermatid developmentdefinition[GO:0007286] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27125
PRO: PR:Q9UHB7