UBQLN2 - Ubiquilin-2 - human protein (Function)
 
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Protein
Gene
References

 
UBQLN2 »  Ubiquilin-2
 
Protein also known as:  Protein linking IAP with cytoskeleton 2 (PLIC-2).
Gene name:  UBQLN2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed24215460, PubMed18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed19148225, PubMed20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed18199683).  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
GO biological process 
Autophagydefinition[GO:0006914]  
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  • UniProtKB KW
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
1
  • UniProtKB
Negative regulation of clathrin-mediated endocytosisdefinition[GO:1900186]  
1
  • UniProtKB
Negative regulation of G-protein coupled receptor internalizationdefinition[GO:1904021]  
1
  • UniProtKB
Positive regulation of ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:1903071]  
1
  • UniProtKB
Regulation of autophagosome assemblydefinition[GO:2000785]  
1
  • UniProtKB
Regulation of macroautophagydefinition[GO:0016241]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+29978  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBQLN2
GenomeRNAi: 29978
PRO: PR:Q9UHD9