SLC7A8 - Large neutral amino acids transporter small subunit 2 - human protein (Function)
 
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Protein
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SLC7A8 »  Large neutral amino acids transporter small subunit 2
 
Protein also known as:  Solute carrier family 7 member 8.
Gene name:  SLC7A8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the amino acid-polyamine-organocation (apc) family  2.A.3.8.20  
GO molecular function 
Amino acid transmembrane transporter activitydefinition[GO:0015171]  
3
  • IDAUniProtKB
  • ISSOrtholog Curator
L-amino acid transmembrane transporter activitydefinition[GO:0015179] silver  
  • IEAOrtholog Compara
Neutral amino acid transmembrane transporter activitydefinition[GO:0015175]  
1
  • TASPINC
Organic cation transmembrane transporter activitydefinition[GO:0015101]  
1
  • IDAUniProtKB
Peptide antigen bindingdefinition[GO:0042605]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Toxin transporter activitydefinition[GO:0019534]  
1
  • IDAUniProtKB
GO biological process 
Amino acid transportdefinition[GO:0006865]  
3
  • IDAUniProtKB
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • TASPINC
Metal ion homeostasisdefinition[GO:0055065]  
1
  • NASUniProtKB
Neutral amino acid transportdefinition[GO:0015804]  
  • ISSOrtholog Curator
Organic cation transportdefinition[GO:0015695]  
1
  • IDAGOC
Response to toxic substancedefinition[GO:0009636]  
1
  • NASUniProtKB
Toxin transportdefinition[GO:1901998]  
1
  • IDAGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+23428  
According to Reactome, this protein belongs to the following pathways:
Amino acid and oligopeptide SLC transporters  REACT_19419  
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
Note 
L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. Glycine, alanine, serine, threonine asparginine, glutamine, methionine, leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, histidine and cysteine) and by glutamine and asparginine. Methionine uptake was inhibited by the L-system substrates L-leucine, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 978 uM for L-alanine
KM 48.8 uM for L-tyrosine
KM 57.3 uM for L-tryptophan
KM 161 uM for methionine
KM 221 uM for L-leucine
KM 64 uM for MeHg-L-cysteine
KM 89.35 uM for L-phenylalanine

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UHI5
Other
GeneWiki: SLC7A8
GenomeRNAi: 23428
PRO: PR:Q9UHI5