ADAMTS1 - A disintegrin and metalloproteinase with thrombospondin motifs 1 - human protein (Function)
 
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ADAMTS1 »  A disintegrin and metalloproteinase with thrombospondin motifs 1   [ EC 3.4.24.- ]  (ADAMTS-1)
 
Protein also known as:  METH-1.
Gene name:  ADAMTS1
Entry whose protein(s) existence is based on evidence at protein level
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1 92 1
GENE REF ISO

Function

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Overview 
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.  
2
  • UniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201] silver  
1
  • Ortholog Compara
Metalloendopeptidase activitydefinition[GO:0004222] silver  
1
  • InterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • PINC
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cellular response to parathyroid hormone stimulusdefinition[GO:0071374] silver  
1
  • Ortholog Compara
Cellular response to prostaglandin E stimulusdefinition[GO:0071380] silver  
1
  • Ortholog Compara
Cellular response to vitamin Ddefinition[GO:0071305] silver  
1
  • Ortholog Compara
Heart trabecula formationdefinition[GO:0060347] silver  
1
  • Ortholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • PINC
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Ovulation from ovarian follicledefinition[GO:0001542] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Tooth eruptiondefinition[GO:0044691] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain.  
1
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Degradation of the extracellular matrix  R-HSA-1474228  
O-glycosylation of TSR domain-containing proteins  R-HSA-5173214  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADAMTS1
GenomeRNAi: 9510
PRO: PR:Q9UHI8
Chemistry
GuidetoPHARMACOLOGY: 1674