ADAMTS1 - A disintegrin and metalloproteinase with thrombospondin motifs 1 - human protein (Function)
 
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ADAMTS1 »  A disintegrin and metalloproteinase with thrombospondin motifs 1   [ EC 3.4.24.- ]  (ADAM-TS1)
 
Protein also known as:  METH-1.
Gene name:  ADAMTS1
Entry whose protein(s) existence is based on evidence at protein level
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1 76 1
GENE REF ISO

Function

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Overview 
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.  
1
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAOrtholog Compara
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Heart trabecula formationdefinition[GO:0060347] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • TASPINC
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Ovulation from ovarian follicledefinition[GO:0001542] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Extracellular matrix organization  REACT_133391  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS1
GenomeRNAi: 9510
PRO: PR:Q9UHI8