AMACR - Alpha-methylacyl-CoA racemase - human protein (Function)
 
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AMACR »  Alpha-methylacyl-CoA racemase   [ EC 5.1.99.4 ]
 
Protein also known as:  2-methylacyl-CoA racemase.
Gene name:  AMACR
Entry whose protein(s) existence is based on evidence at protein level
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1 24 4
GENE REF ISO

Function

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Overview 
Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.  
  • CuratedUniProtKB
GO molecular function 
Alpha-methylacyl-CoA racemase activitydefinition[GO:0008111]  
2
  • IMPUniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • IPIUniProtKB
GO biological process 
Bile acid biosynthetic processdefinition[GO:0006699]  
  • IEAUniPathway
Bile acid metabolic processdefinition[GO:0008206]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.99.4: (2S)-2-methylacyl-CoA (2R)-2-methylacyl-CoA.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+23600  
Peroxisome  hsa04146+23600  
Primary bile acid biosynthesis  hsa00120+23600  
According to Reactome, this protein belongs to the following pathways:
Beta-oxidation of pristanoyl-CoA  REACT_17017  
Synthesis of bile acids and bile salts via 24-hydroxycholesterol  REACT_11053  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
 
More information is available from:
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UHK6
Other
GeneWiki: Alpha-methylacyl-CoA_racemase
GenomeRNAi: 23600
PRO: PR:Q9UHK6