DPP7 - Dipeptidyl peptidase 2 - human protein (Function)
 
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DPP7 »  Dipeptidyl peptidase 2   [ EC 3.4.14.2 ]
 
Protein also known as:  Quiescent cell proline dipeptidase.
Gene name:  DPP7
Family name: Peptidase S28
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the degradation of some oligopeptides.  
1
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
  • IEAUniProtKB KW
Dipeptidyl-peptidase activitydefinition[GO:0008239] silver  
  • IEAOrtholog Compara
Serine-type peptidase activitydefinition[GO:0008236]  
  • IEAUniProtKB KW
GO biological process 
Proteolysisdefinition[GO:0006508] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.2: Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.

Keywords

Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DPP7
GenomeRNAi: 29952
PRO: PR:Q9UHL4
Chemistry
GuidetoPHARMACOLOGY: 1605