GTF2IRD1 - General transcription factor II-I repeat domain-containing protein 1 - human protein (Function)
 
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GTF2IRD1 »  General transcription factor II-I repeat domain-containing protein 1  (GTF2I repeat domain-containing protein 1)
 
Protein also known as:  Williams-Beuren syndrome chromosomal region 11 protein.
Gene name:  GTF2IRD1
Family name: TFII-I
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 3
GENE REF ISO

Function

 show evidences
Overview 
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • NASUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASUniProtKB
GO biological process 
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • NASGOC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • NASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+9569  
Herpes simplex infection  hsa05168+9569  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GTF2IRD1
GenomeRNAi: 9569
PRO: PR:Q9UHL9