OPN4 - Melanopsin - human protein (Function)
 
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Protein
Gene
References

 
OPN4 »  Melanopsin
 
Protein also known as:  Opsin-4.
Gene name:  OPN4
Entry whose protein(s) existence is based on evidence at protein level
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1 28 2
GENE REF ISO

Function

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Overview 
Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.8  
GO molecular function 
11-cis retinal bindingdefinition[GO:0005502]  
1
  • IDAUniProtKB
G-protein coupled photoreceptor activitydefinition[GO:0008020]  
1
  • IDAUniProtKB
GO biological process 
Phototransductiondefinition[GO:0007602]  
1
  • IDAUniProtKB
Protein-chromophore linkagedefinition[GO:0018298]  
  • IEAUniProtKB KW
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Rhodopsin mediated signaling pathwaydefinition[GO:0016056] silver  
  • IEAOrtholog Compara
Rhythmic processdefinition[GO:0048511]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Sensory transduction  definition   [KW-0716]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Photoreceptor protein  definition   [KW-0600]
Receptor  definition   [KW-0675]
Retinal protein  definition   [KW-0681]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Melanopsin
GenomeRNAi: 94233
PRO: PR:Q9UHM6