USP25 - Ubiquitin carboxyl-terminal hydrolase 25 - human protein (Function)
 
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USP25 »  Ubiquitin carboxyl-terminal hydrolase 25   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 25.
Gene name:  USP25
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.  
5
  • CuratedUniProtKB
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.  
5
  • CuratedUniProtKB
GO molecular function 
Peptidase activitydefinition[GO:0008233]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
SUMO bindingdefinition[GO:0032183]  
1
  • IDAUniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IMPUniProtKB
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Protein K48-linked deubiquitinationdefinition[GO:0071108]  
1
  • IMPUniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
1
  • IMPUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29761
PRO: PR:Q9UHP3