USP25 - Ubiquitin carboxyl-terminal hydrolase 25 - human protein (Function)
 
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Protein
Gene
References

 
USP25 »  Ubiquitin carboxyl-terminal hydrolase 25   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 25.
Gene name:  USP25
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.  
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  • UniProtKB
The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.  
1
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
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  • RefGenome
Peptidase activitydefinition[GO:0008233]  
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  • PINC
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
SUMO bindingdefinition[GO:0032183]  
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  • UniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
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  • UniProtKB
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
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  • PINC
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
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  • RefGenome
Protein K48-linked deubiquitinationdefinition[GO:0071108]  
1
  • UniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
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  • UniProtKB
Proteolysisdefinition[GO:0006508]  
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  • PINC
Regulation of proteasomal protein catabolic processdefinition[GO:0061136]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29761
PRO: PR:Q9UHP3