CYB5R1 - NADH-cytochrome b5 reductase 1 - human protein (Function)
 
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CYB5R1 »  NADH-cytochrome b5 reductase 1   [ EC 1.6.2.2 ]  (b5R.1)
 
Protein also known as:  NAD(P)H:quinone oxidoreductase type 3 polypeptide A2.
Gene name:  CYB5R1
Entry whose protein(s) existence is based on evidence at protein level
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1 26 1
GENE REF ISO

Function

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Overview 
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Cytochrome-b5 reductase activity, acting on NAD(P)Hdefinition[GO:0004128]  
  • IEAEC 2 GO
GO biological process 
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Sterol biosynthetic processdefinition[GO:0016126]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.2.2: NADH + 2 ferricytochrome b5 NAD(+) + H(+) + 2 ferrocytochrome b5.  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+51706  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYB5R1
GenomeRNAi: 51706
PRO: PR:Q9UHQ9