SLC12A6 - Solute carrier family 12 member 6 - human protein (Function)
 
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Protein
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SLC12A6 »  Solute carrier family 12 member 6
 
Protein also known as:  Electroneutral potassium-chloride cotransporter 3.
Gene name:  SLC12A6
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 51 6
GENE REF ISO

Function

 show evidences
Overview 
Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.5.3  
GO molecular function 
Potassium:chloride symporter activitydefinition[GO:0015379]  
2
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • NASUniProtKB
Cellular hypotonic salinity responsedefinition[GO:0071477]  
1
  • IDAUniProtKB
Chloride transmembrane transportdefinition[GO:1902476]  
2
  • IDAGOC
Chloride transportdefinition[GO:0006821]  
2
  • IDAGOC
Ion transportdefinition[GO:0006811]  
1
  • IDAUniProtKB
Potassium ion transportdefinition[GO:0006813]  
  • IEAUniProtKB KW
Enzymatic activity 
It is regulated in the following manner
Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Biophysicochemical properties

Kinetic parameters
KM 10.7 mM for extracellular Rb(+) (isoform 1)
KM 17.2 mM for extracellular Rb(+) (isoform 2)
KM 7.3 mM for extracellular Cl(-) (isoform 1)
KM 8.2 mM for extracellular Cl(-) (isoform 2)

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC12A6
GenomeRNAi: 9990
PRO: PR:Q9UHW9
Chemistry
GuidetoPHARMACOLOGY: 973