EMR2 - EGF-like module-containing mucin-like hormone receptor-like 2 - human protein (Function)
 
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EMR2 »  EGF-like module-containing mucin-like hormone receptor-like 2
 
Protein also known as:  CD antigen CD312.
Gene name:  EMR2
Entry whose protein(s) existence is based on evidence at protein level
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1 33 6
GENE REF ISO

Function

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Overview 
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.  
3
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Chondroitin sulfate bindingdefinition[GO:0035374]  
1
  • IMPUniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • IMPUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASGDB
Granulocyte chemotaxisdefinition[GO:0071621]  
1
  • IMPUniProtKB
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Class B/2 (Secretin family receptors)  REACT_18372  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Inflammatory response  definition   [KW-0395]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EMR2
GenomeRNAi: 30817
PRO: PR:Q9UHX3