SCN11A - Sodium channel protein type 11 subunit alpha - human protein (Function)
 
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SCN11A »  Sodium channel protein type 11 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.9.
Gene name:  SCN11A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.10.9  
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248]  
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  • RefGenome
GO biological process 
Membrane depolarization during action potentialdefinition[GO:0086010]  
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  • RefGenome
Neuronal action potentialdefinition[GO:0019228]  
1
  • RefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765]  
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  • UniProtKB KW
Regulation of sensory perception of paindefinition[GO:0051930]  
1
  • Ortholog Curator
Response to drugdefinition[GO:0042493]  
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  • PINC
Sodium ion transmembrane transportdefinition[GO:0035725]  
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  • RefGenome
Sodium ion transportdefinition[GO:0006814]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Nav1.9
GenomeRNAi: 11280
PRO: PR:Q9UI33