BAZ2A - Bromodomain adjacent to zinc finger domain protein 2A - human protein (Function)
 
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Protein
Gene
References

 
BAZ2A »  Bromodomain adjacent to zinc finger domain protein 2A
 
Protein also known as:  Transcription termination factor I-interacting protein 5 (Tip5).
Gene name:  BAZ2A
Family name: WAL
Entry whose protein(s) existence is based on evidence at protein level
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1 32 3
GENE REF ISO

Function

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Overview 
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Histone acetyl-lysine bindingdefinition[GO:0070577]  
  • ISSOrtholog Curator
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • NASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
1
  • NASUniProtKB
Chromatin silencing at rDNAdefinition[GO:0000183]  
  • ISSOrtholog Curator
DNA methylationdefinition[GO:0006306]  
  • ISSOrtholog Curator
Heterochromatin assembly involved in chromatin silencingdefinition[GO:0070869] silver  
  • IEAOrtholog Compara
Histone deacetylationdefinition[GO:0016575]  
  • ISSOrtholog Curator
Histone H3-K9 methylationdefinition[GO:0051567] silver  
  • IEAOrtholog Compara
Histone H4 deacetylationdefinition[GO:0070933] silver  
  • IEAOrtholog Compara
Histone H4-K20 methylationdefinition[GO:0034770] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • NASUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAZ2A
GenomeRNAi: 11176
PRO: PR:Q9UIF9