KLF15 - Krueppel-like factor 15 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
KLF15 »  Krueppel-like factor 15
 
Protein also known as:  Kidney-enriched krueppel-like factor.
Gene name:  KLF15
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.  
4
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • ICBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to peptidedefinition[GO:1901653] silver  
  • IEAOrtholog Compara
Glial cell differentiationdefinition[GO:0010001] silver  
  • IEAOrtholog Compara
Glomerular visceral epithelial cell differentiationdefinition[GO:0072112]  
  • ISSOrtholog Curator
Glucose transportdefinition[GO:0015758] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-lysine acetylationdefinition[GO:2000757]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KLF15
GenomeRNAi: 28999
PRO: PR:Q9UIH9