AK3 - GTP:AMP phosphotransferase AK3, mitochondrial - human protein (Function)
 
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References

 
AK3 »  GTP:AMP phosphotransferase AK3, mitochondrial   [ EC 2.7.4.10 ]
 
Protein also known as:  Adenylate kinase 3 alpha-like 1.
Gene name:  AK3
Family name: Adenylate kinase » AK3
Entry whose protein(s) existence is based on evidence at protein level
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1 15 3
GENE REF ISO

Function

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Overview 
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.  
1
  • CuratedUniProtKB
GO molecular function 
Not  Adenylate kinase activitydefinition[GO:0004017]  
1
  • IDABHF-UCL
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Nucleoside triphosphate adenylate kinase activitydefinition[GO:0046899]  
1
  • IDABHF-UCL
GO biological process 
AMP metabolic processdefinition[GO:0046033]  
1
  • IDABHF-UCL
GTP metabolic processdefinition[GO:0046039]  
1
  • IDABHF-UCL
ITP metabolic processdefinition[GO:0046041]  
1
  • IDABHF-UCL
UTP metabolic processdefinition[GO:0046051]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.4.10: NTP + AMP NDP + ADP.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pyrimidine metabolism  hsa00240+50808  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 50808
PRO: PR:Q9UIJ7