DAPK2 - Death-associated protein kinase 2 - human protein (Function)
 
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DAPK2 »  Death-associated protein kinase 2
 
Gene name:  DAPK2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 2
GENE REF ISO

Function

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Overview 
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.  
7
  • CuratedUniProtKB
Isoform  Iso 2   Is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • IDAUniProtKB
Calmodulin-dependent protein kinase activitydefinition[GO:0004683] silver  
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASUniProtKB
GO biological process 
Anoikisdefinition[GO:0043276]  
1
  • IMPUniProtKB
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • TASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of autophagydefinition[GO:0010506]  
1
  • TASUniProtKB
Regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001242]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
3
  • CuratedUniProtKB
It is regulated in the following manner
Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involving autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318, release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinase.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+23604  
Pathways in cancer  hsa05200+23604  
According to Reactome, this protein belongs to the following pathway:
Role of DCC in regulating apoptosis  REACT_22128  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DAPK2
GenomeRNAi: 23604
PRO: PR:Q9UIK4
Chemistry
GuidetoPHARMACOLOGY: 2003