MBD1 - Methyl-CpG-binding domain protein 1 - human protein (Function)
 
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Protein
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References

 
MBD1 »  Methyl-CpG-binding domain protein 1
 
Protein also known as:  Protein containing methyl-CpG-binding domain 1.
Gene name:  MBD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.  
10
  • CuratedUniProtKB
Isoforms  Iso 1 and Iso 2   Can also repress transcription from unmethylated promoters.  
10
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Methyl-CpG bindingdefinition[GO:0008327]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • NASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MBD1
GenomeRNAi: 4152
PRO: PR:Q9UIS9