RABGEF1 - Rab5 GDP/GTP exchange factor - human protein (Function)
 
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RABGEF1 »  Rab5 GDP/GTP exchange factor
 
Protein also known as:  Rabaptin-5-associated exchange factor for Rab5.
Gene name:  RABGEF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 4
GENE REF ISO

Function

 show evidences
Overview 
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Rab GTPase bindingdefinition[GO:0017137]  
1
  • UniProtKB
Rab guanyl-nucleotide exchange factor activitydefinition[GO:0017112]  
2
  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Endocytosisdefinition[GO:0006897]  
1
  • UniProtKB KW
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of interleukin-6 secretiondefinition[GO:1900165] silver  
1
  • Ortholog Compara
Negative regulation of Kit signaling pathwaydefinition[GO:1900235] silver  
1
  • Ortholog Compara
Negative regulation of leukocyte migrationdefinition[GO:0002686] silver  
1
  • Ortholog Compara
Negative regulation of mast cell degranulationdefinition[GO:0043305] silver  
1
  • Ortholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
1
  • Ortholog Compara
Negative regulation of Ras protein signal transductiondefinition[GO:0046580] silver  
1
  • Ortholog Compara
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261] silver  
1
  • Ortholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • GOC
Protein targeting to membranedefinition[GO:0006612]  
1
  • UniProtKB
Protein ubiquitinationdefinition[GO:0016567] silver  
1
  • Ortholog Compara
Regulation of Fc receptor mediated stimulatory signaling pathwaydefinition[GO:0060368] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RABGEF1
GenomeRNAi: 27342
PRO: PR:Q9UJ41