RABGEF1 - Rab5 GDP/GTP exchange factor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
RABGEF1 »  Rab5 GDP/GTP exchange factor
 
Protein also known as:  Rabaptin-5-associated exchange factor for Rab5.
Gene name:  RABGEF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 4
GENE REF ISO

Function

 show evidences
Overview 
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).  
3
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Rab guanyl-nucleotide exchange factor activitydefinition[GO:0017112]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Positive regulation of Rab GTPase activitydefinition[GO:0032851]  
1
  • IDAGOC
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RABGEF1
GenomeRNAi: 27342
PRO: PR:Q9UJ41