NAGK - N-acetyl-D-glucosamine kinase - human protein (Function)
 
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NAGK »  N-acetyl-D-glucosamine kinase   [ EC 2.7.1.59 ]  (N-acetylglucosamine kinase)
 
Protein also known as:  GlcNAc kinase.
Gene name:  NAGK
Entry whose protein(s) existence is based on evidence at protein level
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1 41 2
GENE REF ISO

Function

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Overview 
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
N-acetylglucosamine kinase activitydefinition[GO:0045127]  
1
  • IDAUniProtKB
N-acylmannosamine kinase activitydefinition[GO:0009384] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
1
  • IDAGOC
  • IEAEC 2 GO
  • IEAOrtholog Compara
N-acetylglucosamine metabolic processdefinition[GO:0006044] silver  
  • IEAOrtholog Compara
N-acetylmannosamine metabolic processdefinition[GO:0006051]  
1
  • TASPINC
N-acetylneuraminate catabolic processdefinition[GO:0019262]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.59: ATP + N-acetyl-D-glucosamine ADP + N-acetyl-D-glucosamine 6-phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+55577  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NAGK
GenomeRNAi: 55577
PRO: PR:Q9UJ70