HACL1 - 2-hydroxyacyl-CoA lyase 1 - human protein (Function)
 
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Protein
Gene
References

 
HACL1 »  2-hydroxyacyl-CoA lyase 1   [ EC 4.1.-.- ]
 
Protein also known as:  Phytanoyl-CoA 2-hydroxylase 2.
Gene name:  HACL1
Family name: TPP enzyme
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 4
GENE REF ISO

Function

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Overview 
Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.  
  • CuratedUniProtKB
GO molecular function 
Carbon-carbon lyase activitydefinition[GO:0016830]  
3
  • IDAUniProtKB
  • IDAHGNC
Cofactor bindingdefinition[GO:0048037]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Thiamine pyrophosphate bindingdefinition[GO:0030976]  
2
  • IDAUniProtKB
  • IDAHGNC
GO biological process 
Fatty acid alpha-oxidationdefinition[GO:0001561]  
1
  • IDAHGNC
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.-.-: 2-hydroxyphytanoyl-CoA pristanal + formyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 magnesium ion per subunit.  
  • CuratedUniProtKB
Binds 1 thiamine pyrophosphate per subunit.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+26061  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26061
PRO: PR:Q9UJ83