FOXD3 - Forkhead box protein D3 - human protein (Function)
 
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Protein
Gene
References

 
FOXD3 »  Forkhead box protein D3
 
Protein also known as:  HNF3/FH transcription factor genesis.
Gene name:  FOXD3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001227]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
GO biological process 
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IBARefGenome
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  REACT_200759  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXD3
GenomeRNAi: 27022
PRO: PR:Q9UJU5