FOXD3 - Forkhead box protein D3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FOXD3 »  Forkhead box protein D3
 
Protein also known as:  HNF3/FH transcription factor genesis.
Gene name:  FOXD3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IBARefGenome
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001227]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134] silver  
  • IBARefGenome
GO biological process 
Axon extension involved in axon guidancedefinition[GO:0048846] silver  
  • IBARefGenome
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IBARefGenome
Cartilage developmentdefinition[GO:0051216] silver  
  • IBARefGenome
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IBARefGenome
Enteric nervous system developmentdefinition[GO:0048484] silver  
  • IBARefGenome
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Iridophore differentiationdefinition[GO:0050935] silver  
  • IBARefGenome
Kidney developmentdefinition[GO:0001822] silver  
  • IBARefGenome
Lateral line nerve glial cell developmentdefinition[GO:0048937] silver  
  • IBARefGenome
Melanocyte differentiationdefinition[GO:0030318] silver  
  • IBARefGenome
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IBARefGenome
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Peripheral nervous system developmentdefinition[GO:0007422] silver  
  • IBARefGenome
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090] silver  
  • IBARefGenome
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
  • IBARefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IBARefGenome
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
  • IBARefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXD3
GenomeRNAi: 27022
PRO: PR:Q9UJU5