DBNL - Drebrin-like protein - human protein (Function)
 
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DBNL »  Drebrin-like protein
 
Protein also known as:  HPK1-interacting protein of 55 kDa (HIP-55).
Gene name:  DBNL
Family name: ABP1
Entry whose protein(s) existence is based on evidence at protein level
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1 76 5
GENE REF ISO

Function

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Overview 
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • ISSOrtholog Curator
Actin filament bindingdefinition[GO:0051015]  
  • ISSOrtholog Curator
Enzyme activator activitydefinition[GO:0008047]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • TASPINC
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Immune system processdefinition[GO:0002376]  
  • IEAUniProtKB KW
Neuron projection morphogenesisdefinition[GO:0048812]  
  • ISSOrtholog Curator
Podosome assemblydefinition[GO:0071800]  
  • ISSOrtholog Curator
Rac protein signal transductiondefinition[GO:0016601]  
  • ISSOrtholog Curator
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Endocytosis  definition   [KW-0254]
Immunity  definition   [KW-0391]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Drebrin-like
GenomeRNAi: 28988
PRO: PR:Q9UJU6