ANAPC4 - Anaphase-promoting complex subunit 4 - human protein (Function)
 
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References

 
ANAPC4 »  Anaphase-promoting complex subunit 4
 
Gene name:  ANAPC4
Family name: APC4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIBHF-UCL
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • TASPINC
GO biological process 
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • TASPINC
Mitotic anaphasedefinition[GO:0000090]  
1
  • TASPINC
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Protein K11-linked ubiquitinationdefinition[GO:0070979]  
1
  • IDAUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • TASPINC
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+29945  
HTLV-I infection  hsa05166+29945  
Oocyte meiosis  hsa04114+29945  
Progesterone-mediated oocyte maturation  hsa04914+29945  
Ubiquitin mediated proteolysis  hsa04120+29945  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
APC/C:Cdc20 mediated degradation of Cyclin B  REACT_6820  
APC/C:Cdc20 mediated degradation of mitotic proteins  REACT_6781  
APC/C:Cdc20 mediated degradation of Securin  REACT_6871  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Autodegradation of Cdh1 by Cdh1:APC/C  REACT_6785  
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase  REACT_6867  
Inactivation of APC/C via direct inhibition of the APC/C complex  REACT_1072  
Phosphorylation of the APC/C  REACT_6904  
Regulation of APC/C activators between G1/S and early anaphase  REACT_6837  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
Separation of Sister Chromatids  REACT_150471  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ANAPC4
GenomeRNAi: 29945
PRO: PR:Q9UJX5