RPS6KA6 - Ribosomal protein S6 kinase alpha-6 - human protein (Function)
 
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RPS6KA6 »  Ribosomal protein S6 kinase alpha-6   [ EC 2.7.11.1 ]  (S6K-alpha-6)
 
Protein also known as:  90 kDa ribosomal protein S6 kinase 6 (p90RSK6).
Gene name:  RPS6KA6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • IMPUniProtKB
Negative regulation of embryonic developmentdefinition[GO:0045992]  
  • ISSOrtholog Curator
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
  • ISSOrtholog Curator
Negative regulation of mesoderm developmentdefinition[GO:2000381]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Long-term potentiation  hsa04720+27330  
MAPK signaling pathway  hsa04010+27330  
mTOR signaling pathway  hsa04150+27330  
Neurotrophin signaling pathway  hsa04722+27330  
Oocyte meiosis  hsa04114+27330  
Progesterone-mediated oocyte maturation  hsa04914+27330  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Neuronal System  REACT_13685  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 27330
PRO: PR:Q9UK32
Chemistry
GuidetoPHARMACOLOGY: 1530