VPS28 - Vacuolar protein sorting-associated protein 28 homolog - human protein (Function)
 
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VPS28 »  Vacuolar protein sorting-associated protein 28 homolog  (H-Vps28)
 
Protein also known as:  ESCRT-I complex subunit VPS28.
Gene name:  VPS28
Family name: VPS28
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 2
GENE REF ISO

Function

 show evidences
Overview 
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • RefGenome
Ubiquitin bindingdefinition[GO:0043130]  
1
  • UniProtKB
GO biological process 
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
1
  • UniProtKB
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • UniProtKB
Positive regulation of ubiquitin-dependent endocytosisdefinition[GO:2000397]  
1
  • UniProtKB
Protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043328]  
1
  • RefGenome
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043162]  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+51160  
According to Reactome, this protein belongs to the following pathways:
Budding and maturation of HIV virion  REACT_6359  
Endosomal Sorting Complex Required For Transport (ESCRT)  REACT_27258  
Membrane binding and targetting of GAG proteins  REACT_115893  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: VPS28
GenomeRNAi: 51160
PRO: PR:Q9UK41