FEM1B - Protein fem-1 homolog B - human protein (Function)
 
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FEM1B »  Protein fem-1 homolog B  (FEM1b)
 
Protein also known as:  Fem-1-like death receptor-binding protein alpha.
Gene name:  FEM1B
Family name: Fem-1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.  
2
  • CuratedUniProtKB
GO molecular function 
Death receptor bindingdefinition[GO:0005123]  
2
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IMPUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Branching involved in prostate gland morphogenesisdefinition[GO:0060442] silver  
  • IEAOrtholog Compara
Epithelial cell maturation involved in prostate gland developmentdefinition[GO:0060743] silver  
  • IEAOrtholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Regulation of DNA damage checkpointdefinition[GO:2000001]  
1
  • IMPUniProtKB
Regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902041]  
1
  • IMPUniProtKB
Regulation of ubiquitin-protein transferase activitydefinition[GO:0051438]  
1
  • IMPUniProtKB
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10116
PRO: PR:Q9UK73