ADAM21 - Disintegrin and metalloproteinase domain-containing protein 21 - human protein (Function)
 
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ADAM21 »  Disintegrin and metalloproteinase domain-containing protein 21   [ EC 3.4.24.- ]  (ADAM 21)
 
Gene name:  ADAM21
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.  
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  • UniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
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  • InterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
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  • PINC
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
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  • UniProtKB KW
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction With The Zona Pellucida  REACT_163933  
Note 
May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human.  
1
  • UniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8747
PRO: PR:Q9UKJ8