ADAMTS7 - A disintegrin and metalloproteinase with thrombospondin motifs 7 - human protein (Function)
 
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ADAMTS7 »  A disintegrin and metalloproteinase with thrombospondin motifs 7   [ EC 3.4.24.- ]  (ADAMTS-7)
 
Protein also known as:  COMPase.
Gene name:  ADAMTS7
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
Metalloprotease that may play a role in the degradation of COMP.  
1
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • IDABHF-UCL
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • IDABHF-UCL
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IMPBHF-UCL
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IMPBHF-UCL
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
1
  • IDABHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IMPBHF-UCL
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
O-glycosylation of TSR domain-containing proteins  REACT_200626  
 

Biophysicochemical properties

Dependence
pH Optimum pH is between 7.5 and 9.5.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11173
PRO: PR:Q9UKP4