PACSIN3 - Protein kinase C and casein kinase substrate in neurons protein 3 - human protein (Function)
 
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PACSIN3 »  Protein kinase C and casein kinase substrate in neurons protein 3
 
Protein also known as:  SH3 domain-containing protein 6511.
Gene name:  PACSIN3
Family name: PACSIN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).  
1
  • UniProtKB
GO molecular function 
Calcium channel inhibitor activitydefinition[GO:0019855]  
1
  • Ortholog Curator
Cytoskeletal protein bindingdefinition[GO:0008092]  
2
  • Ortholog Curator
  • RefGenome
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB
Phospholipid bindingdefinition[GO:0005543]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
GO biological process 
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • RefGenome
Endocytosisdefinition[GO:0006897]  
1
  • UniProtKB KW
Membrane tubulationdefinition[GO:0097320]  
1
  • UniProtKB
Negative regulation of calcium ion transportdefinition[GO:0051926]  
1
  • Ortholog Curator
Negative regulation of endocytosisdefinition[GO:0045806]  
1
  • Ortholog Curator
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • BHF-UCL
Regulation of endocytosisdefinition[GO:0030100]  
1
  • RefGenome
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PACSIN3
GenomeRNAi: 29763
PRO: PR:Q9UKS6