IKZF3 - Zinc finger protein Aiolos - human protein (Function)
 
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IKZF3 »  Zinc finger protein Aiolos
 
Protein also known as:  Ikaros family zinc finger protein 3.
Gene name:  IKZF3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.  
2
  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • Ortholog Curator
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • RefGenome
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingdefinition[GO:0001228] silver  
1
  • Ortholog Compara
GO biological process 
B cell activationdefinition[GO:0042113]  
1
  • UniProtKB KW
Mesoderm developmentdefinition[GO:0007498]  
1
  • PINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • UniProtKB
Regulation of B cell differentiationdefinition[GO:0045577]  
1
  • Ortholog Curator
Regulation of B cell proliferationdefinition[GO:0030888]  
1
  • Ortholog Curator
Regulation of lymphocyte differentiationdefinition[GO:0045619]  
1
  • Ortholog Curator
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
B-cell activation  definition   [KW-0075]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IKZF3
GenomeRNAi: 22806
PRO: PR:Q9UKT9