ACSL6 - Long-chain-fatty-acid--CoA ligase 6 - human protein (Function)
 
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ACSL6 »  Long-chain-fatty-acid--CoA ligase 6   [ EC 6.2.1.3 ]
 
Protein also known as:  Long-chain acyl-CoA synthetase 6 (LACS 6).
Gene name:  ACSL6
Entry whose protein(s) existence is based on evidence at protein level
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1 29 9
GENE REF ISO

Function

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Overview 
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Isoforms  Iso 1 , Iso 7 and Iso 8   Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
2
  • IDAUniProtKB
Isoforms  Iso 1 , Iso 7 and Iso 8   Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Acyl-CoA metabolic processdefinition[GO:0006637]  
1
  • NASUniProtKB
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
Fatty acid transportdefinition[GO:0015908] silver  
  • IEAOrtholog Compara
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Neuroblast proliferationdefinition[GO:0007405] silver  
  • IEAOrtholog Compara
Neuron developmentdefinition[GO:0048666] silver  
  • IEAOrtholog Compara
Phospholipid biosynthetic processdefinition[GO:0008654] silver  
  • IEAOrtholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
  • IEAOrtholog Compara
Positive regulation of plasma membrane long-chain fatty acid transportdefinition[GO:0010747] silver  
  • IEAOrtholog Compara
Positive regulation of triglyceride biosynthetic processdefinition[GO:0010867] silver  
  • IEAOrtholog Compara
Response to gravitydefinition[GO:0009629] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+23305  
Fatty acid metabolism  hsa00071+23305  
Metabolic pathways  hsa01100+23305  
Peroxisome  hsa04146+23305  
PPAR signaling pathway  hsa03320+23305  
According to Reactome, this protein belongs to the following pathway:
Synthesis of very long-chain fatty acyl-CoAs  REACT_380  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSL6
GenomeRNAi: 23305
PRO: PR:Q9UKU0