ACAD8 - Isobutyryl-CoA dehydrogenase, mitochondrial - human protein (Function)
 
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ACAD8 »  Isobutyryl-CoA dehydrogenase, mitochondrial   [ EC 1.3.99.- ]
 
Protein also known as:  Activator-recruited cofactor 42 kDa component (ARC42).
Gene name:  ACAD8
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 18 3
GENE REF ISO

Function

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Overview 
Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.  
2
  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
GO biological process 
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Valine catabolic processdefinition[GO:0006574]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.99.-: Isobutyryl-CoA + ETF methylacrylyl-CoA + reduced ETF.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+27034  
Valine, leucine and isoleucine degradation  hsa00280+27034  
According to Reactome, this protein belongs to the following pathway:
Branched-chain amino acid catabolism  REACT_197  
 

Keywords

Biological process 
Branched-chain amino acid catabolism  definition   [KW-0101]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACAD8
GenomeRNAi: 27034
PRO: PR:Q9UKU7