ACIN1 - Apoptotic chromatin condensation inducer in the nucleus - human protein (Function)
 
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ACIN1 »  Apoptotic chromatin condensation inducer in the nucleus  (Acinus)
 
Gene name:  ACIN1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
ATPase activitydefinition[GO:0016887]  
1
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • NASUniProtKB
Nucleic acid bindingdefinition[GO:0003676]  
1
  • NASUniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Apoptotic chromosome condensationdefinition[GO:0030263]  
1
  • IDAUniProtKB
ATP catabolic processdefinition[GO:0006200]  
1
  • NASGOC
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • IEPUniProtKB
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
Isoforms  Iso 1 and Iso 3   Negative regulation of mRNA splicing, via spliceosomedefinition[GO:0048025]  
1
  • IDAUniProtKB
Isoforms  Iso 1 and Iso 3   Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of monocyte differentiationdefinition[GO:0045657]  
1
  • IEPUniProtKB
RNA splicingdefinition[GO:0008380]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
mRNA surveillance pathway  hsa03015+22985  
RNA transport  hsa03013+22985  
Spliceosome  hsa03040+22985  
According to Reactome, this protein belongs to the following pathway:
Apoptosis  REACT_578  
Caution 
Structural and functional studies of the ASAP complex have been conducted with a chimeric complex involving a conserved fragment of Drosophila melanogaster Acinus/hkl (PubMed22388736).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACIN1
GenomeRNAi: 22985
PRO: PR:Q9UKV3