AMFR - E3 ubiquitin-protein ligase AMFR - human protein (Function)
 
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Protein
Gene
References

 
AMFR »  E3 ubiquitin-protein ligase AMFR
 
Gene name:  AMFR
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.  
4
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Receptor activitydefinition[GO:0004872]  
1
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
5
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • IMPUniProtKB
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
3
  • IDAUniProtKB
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
2
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
2
  • IMPUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+267  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AMFR
GenomeRNAi: 267
PRO: PR:Q9UKV5