VAV3 - Guanine nucleotide exchange factor VAV3 - human protein (Function)
 
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VAV3 »  Guanine nucleotide exchange factor VAV3  (VAV-3)
 
Gene name:  VAV3
Entry whose protein(s) existence is based on evidence at protein level
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1 62 4
GENE REF ISO

Function

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Overview 
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).  
1
  • UniProtKB
GO molecular function 
Epidermal growth factor receptor bindingdefinition[GO:0005154] silver  
1
  • Ortholog Compara
GTPase activator activitydefinition[GO:0005096]  
1
  • PINC
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
Rac guanyl-nucleotide exchange factor activitydefinition[GO:0030676] silver  
1
  • Ortholog Compara
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • PINC
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • UniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Integrin-mediated signaling pathwaydefinition[GO:0007229] silver  
1
  • Ortholog Compara
Lamellipodium assemblydefinition[GO:0030032] silver  
1
  • Ortholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
1
  • Ortholog Compara
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • UniProtKB
Positive regulation of cell adhesiondefinition[GO:0045785] silver  
1
  • Ortholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • GOC
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552] silver  
1
  • Ortholog Compara
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • Ortholog Compara
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • GOC
Regulation of Rac GTPase activitydefinition[GO:0032314] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
Vesicle fusiondefinition[GO:0006906] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+10451  
Chemokine signaling pathway  hsa04062+10451  
Fc epsilon RI signaling pathway  hsa04664+10451  
Fc gamma R-mediated phagocytosis  hsa04666+10451  
Focal adhesion  hsa04510+10451  
Leukocyte transendothelial migration  hsa04670+10451  
Natural killer cell mediated cytotoxicity  hsa04650+10451  
Regulation of actin cytoskeleton  hsa04810+10451  
T cell receptor signaling pathway  hsa04660+10451  
According to Reactome, this protein belongs to the following pathways:
DAP12 signaling  REACT_147814  
EPH-ephrin mediated repulsion of cells  REACT_228189  
FCERI mediated Ca+2 mobilization  REACT_163834  
FCERI mediated MAPK activation  REACT_163701  
G alpha (12/13) signalling events  REACT_18407  
GPVI-mediated activation cascade  REACT_1695  
NRAGE signals death through JNK  REACT_13638  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Rho GTPase cycle  REACT_11051  
VEGFA-VEGFR2 Pathway  REACT_228166  
VEGFR2 mediated vascular permeability  REACT_228016  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: VAV3
GenomeRNAi: 10451
PRO: PR:Q9UKW4